Ethyl 6-fluoroimidazo[1,2-a]pyridine-2-carboxylate → 6-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid

HRID 1060815Notes

Reaction equation

HRID 1060815 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][N:9]2[CH:15]=1)=[O:5])C>Cl>[F:14][C:11]1[CH:12]=[CH:13][C:8]2[N:9]([CH:15]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:10]=1

Participants

3

Reactant 1

HCID 40148106Ethyl 6-fluoroimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 223975086-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acidYield 99.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1 g) in 4N HCl was refluxed for 4 hours. The solvent was evaporated to give the sub-title compound as a white solid (0.86 g).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-251936d88d474e4da44ae21b21de51b1
Source dataset
uspto-grants-2003_02
Patent number
US06525070B2

Reaction notes

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