反应详情

温度

35 °C

6,11-Dihydrodibenzo[b,e]oxepin-11-ol (1.06 g, 5 mmol) was dissolved in dry THF (25 mL) at 0° C. Sodium hydride (0.24 g of 50% mineral oil dispersion, 5 mmol) was added portionwise at 0° C. and then refluxed for 30 min. tert-Butylbromoacetate (980 mg, 5.0 mmol) in dry THF (10 mL) was added over a period of 20 and the mixture stirred at 35° C. for 16 h. The reaction mixture was quenched with water at 0° C. and the product extracted with ether. The combined extracts were dried (MgSO4), and concentrated in vacuo. The product was redissolved in ether and added dropwise to an ether (15 mL) suspension of lithium aluminium hydride (190 mg, 5.0 mmol). The reaction was stirred 48 h at room temperature, quenched with water, cooled, and filtered through Decalit. The ether solution was washed with saturated NaCl, dried, and purified by chromatography eluting with ethyl acetate/dichloromethan (1:10) to give 267 mg (21%) of 2-(6,11-dihydrodibenzo[b,e]oxepin-11-yloxy)-ethanol.

1. customThe reaction mixture was quenched with water at 0° C.
2. extractionthe product extracted with ether
3. dry with materialThe combined extracts were dried (MgSO4)
4. concentrationconcentrated in vacuo
5. dissolutionThe product was redissolved in ether
6. stirringThe reaction was stirred 48 h at room temperature
7. customquenched with water
8. temperaturecooled
9. filtrationfiltered through Decalit
10. washThe ether solution was washed with saturated NaCl
11. customdried
12. custompurified by chromatography
13. washeluting with ethyl acetate/dichloromethan (1:10)