Hydrochloric Acid → HCID 86758854, compound

HRID 1060889Notes

Reaction equation

HRID 1060889 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:17]S(CC(C)C)=O)([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH3:10])=[CH:5][C:4]=1[F:24])#[N:2].[ClH:25].O1CCOCC1>CO>[ClH:25].[ClH:25].[NH2:17][C:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([F:24])[CH:5]=1)([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 18629424HCID 18629424, compound

Product 1

HCID 86758854HCID 86758854, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[1-(4-cyano-3-fluoro-phenyl)-1-(3-pyridyl)-ethyl]-2-methylpropanesulfinamide (0.080 g, 0.232 mmol) was dissolved in MeOH (5 mL) and treated with 4M HCl solution in dioxane (0.58 mL, 2.32 mmol). The solution was stirred for 4 h, concentrated to dryness, and azeotroped with CH2Cl2 and Et2O to give the title compound.

Workup

  1. concentrationconcentrated to dryness
  2. customazeotroped with CH2Cl2 and Et2O

Sources & evidence

ORD record
ord-54252ce68eb24bacad2e62c126ef2ad8
Source dataset
uspto-grants-2003_02
Patent number
US06525074B2

Reaction notes

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