反应详情

温度

90 °C

In N,N-dimethylformamide (25 ml), methyl 4-trifluoromethanesulfonyloxybenzoate (1.05 g), 1-methoxycarbonyl-3-pyrroline (1.0 g), lithium chloride (0.51 g), palladium (II) acetate(53 mg) and tri(2-furyl)phosphine (100 mg) were dissolved, followed by the addition of diisopropylethylamine (2.8 ml). Under an argon gas atmosphere, the resulting mixture was stirred at 90° C. for 11 hours and then, at 100° C. for 7 hours. The residue obtained by distilling off the solvent under reduced pressure was added with dichloromethane and water. The organic layer so separated was washed with water and dried over anhydrous sodium sulfate. The solvent was then distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column (hexane:ethyl acetate=9:1˜5:1). The purified product was dissolved in methanol (30 ml), followed by the addition of 10% palladium carbon (water content: about 50%, 186 mg) and ammonium formate (197 mg). The resulting mixture was heated under reflux for 2 hours. After the removal of the catalyst by filtration, the solvent was distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column (10% ethyl acetate-toluene), whereby the title compound (241 mg, 25%) was obtained.

1. waitat 100° C. for 7 hours
2. customThe residue obtained
3. distillationby distilling off the solvent under reduced pressure
4. additionwas added with dichloromethane and water
5. customThe organic layer so separated
6. washwas washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. distillationThe solvent was then distilled off under reduced pressure
9. customThe residue was purified by chromatography on a silica gel column (hexane:ethyl acetate=9:1˜5:1)
10. dissolutionThe purified product was dissolved in methanol (30 ml)
11. additionfollowed by the addition of 10% palladium carbon (water content: about 50%, 186 mg) and ammonium formate (197 mg)
12. temperatureThe resulting mixture was heated
13. temperatureunder reflux for 2 hours
14. customAfter the removal of the catalyst
15. filtrationby filtration
16. distillationthe solvent was distilled off under reduced pressure
17. customThe residue was purified by chromatography on a silica gel column (10% ethyl acetate-toluene), whereby the title compound (241 mg, 25%)
18. customwas obtained