反应详情

[4-chloro-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-3-yl]-carbamic acid tert-butylester (1.8 g) was dissolved in dichloromethane and added trifluoroacetic acid (2 ml) and stirred at room temperature for 2 h. This was carefully basified with ammonium hydroxide solution and extracted the desired amino product with ethyl acetate. The solvent was evaporated to give 4-chloro-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-3-ylamine (0.500 g). MS(ES) 350 (M+H).

1. extractionextracted the desired amino product with ethyl acetate
2. customThe solvent was evaporated