反应详情

To a solution (800 mL) of diisopropylamine (112 mL) and triethylamine (112 mL) in THF was added dropwise a solution (400 mL) of 6-bromo-2-naphthoyl chloride in THF under ice-cooling. The mixture was stirred at room temperature for 1 hr. A half amount of the solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate, washed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine and dried over magnesium sulfate. The solvent was evaporated and the obtained solid was washed with isopropyl ether to give the title compound (117 g) as colorless flakes.

1. temperaturecooling
2. customA half amount of the solvent was evaporated under reduced pressure
3. additionthe residue was diluted with ethyl acetate
4. washwashed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated
7. washthe obtained solid was washed with isopropyl ether