1,1-Dimethylhydrazine → HCID 178450033, compound

HRID 1061889Notes

Reaction equation

HRID 1061889 reaction equation
Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:22])([C:17]3[N:18]=[CH:19][NH:20][CH:21]=3)[CH:14]([CH3:16])[CH3:15])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:23]([O:25]C)=O.[CH3:27][N:28]([CH3:30])[NH2:29]>>[CH3:27][N:28]([CH3:30])[N:29]1[CH2:2][C:3]2[C:12]3[CH:11]=[CH:10][C:9]([C:13]([OH:22])([C:17]4[N:18]=[CH:19][NH:20][CH:21]=4)[CH:14]([CH3:16])[CH3:15])=[CH:8][C:7]=3[CH:6]=[CH:5][C:4]=2[C:23]1=[O:25]

Participants

3

Reactant 2

HCID 59761,1-DimethylhydrazineHCID 178497270HCID 178497270, compound

Product 1

HCID 178450033HCID 178450033, compound

Procedure

By a ring closure reaction, a detritylation reaction and purification in the same manner as in Example 1 using methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-H-imidazol-4-yl)propyl]-2-naphthoate (0.66 g) and 1,1-dimethylhydrazine (1.0 ml), the title compound (0.18 g) was obtained as a colorless amorphous solid.

Workup

  1. customBy a ring closure reaction

Sources & evidence

ORD record
ord-5cda156804d84740bffe94ed2c6ae60f
Source dataset
uspto-grants-2005_11
Patent number
US06960586B2

Reaction notes

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