Hydrochloric Acid → [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid

HRID 1062315ノート

反応式

HRID 1062315 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:8]2[N:23]([CH3:24])[N:22]=[C:21]([CH2:25][CH2:26][CH3:27])[C:9]=2[N:10]=[C:11]([CH2:13][O:14][CH2:15][C:16]([O:18]CC)=[O:17])[N:12]=1.[OH-].[Na+].Cl>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:8]2[N:23]([CH3:24])[N:22]=[C:21]([CH2:25][CH2:26][CH3:27])[C:9]=2[N:10]=[C:11]([CH2:13][O:14][CH2:15][C:16]([OH:18])=[O:17])[N:12]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11408593ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate

生成物 1

HCID 9867548[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.6 4.3 g of ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate are dissolved in 30 ml of tetrahydrofuran (THF), 10 ml of 10% NaOH are added, and the mixture is stirred at 60° for 8 hours. After 10% HCl has been added, the deposited crystals are separated off and recrystallised from methanol, giving 3.7 g of [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid.

後処理

  1. customthe deposited crystals are separated off
  2. customrecrystallised from methanol

出典と根拠

ORDレコード
ord-29314ed1cccc4b82aae9256b738a3b7d
出典データセット
uspto-grants-2005_11
特許番号
US06960661B2

反応ノート

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