Methanol → HCID 22282196, compound

HRID 1062606Notes

Reaction equation

HRID 1062606 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1.[Na].[CH3:20][OH:21]>>[CH3:20][O:21][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 222822075-Chloro-N-(4-fluorophenyl)-2-nitroaniline

Product 1

HCID 22282196HCID 22282196, compound

Conditions

Temperature
60 °C

Procedure

36.44 g (5-chloro-2-nitrophenyl)-(4-fluorophenyl)amine was added to a solution that consists of 6.6 g of sodium in 450 ml of methanol, and it was refluxed for 16 hours. After another 30 hours of stirring at 60° C., it was cooled, and the crystalline product was suctioned off. 34 g of (5-methoxy-2-nitrophenyl)-(4-fluorophenyl)amine was obtained.

Workup

  1. temperaturewas refluxed for 16 hours
  2. temperatureit was cooled

Sources & evidence

ORD record
ord-b4e431d692464d37a9236750d5d5a837
Source dataset
uspto-grants-2005_11
Patent number
US06962932B2

Reaction notes

Loading…