反应详情

(2-Methoxy-5-morpholin-4-yl-phenyl)-thiourea (5.0 g, 19 mmol) in chloroform (130 ml) are treated with bromine (960 □1) and the mixture refluxed for 18 hours. After removal of the volatile components in vacuo, the product is recrystallized from THF (2.8 g, 57%). MS: m/e=266 (M+).

1. temperaturethe mixture refluxed for 18 hours
2. customAfter removal of the volatile components in vacuo
3. customthe product is recrystallized from THF (2.8 g, 57%)