2-Bromoethyl methyl ether → HCID 23401171, compound

HRID 1063209Notes

Reaction equation

HRID 1063209 reaction equation
Br[CH2:2][CH2:3][O:4][CH3:5].[OH:6][C@@H:7]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[Cl:23])[CH:15]=2)=[O:13])[CH2:8]1>>[Cl:23][C:20]1[CH:19]=[CH:18][N:17]=[C:16]2[CH:15]=[C:14]([C:12]([N:9]3[CH2:10][CH2:11][C@H:7]([O:6][CH2:2][CH2:3][O:4][CH3:5])[CH2:8]3)=[O:13])[S:22][C:21]=12

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 207677587-chloro-2-[(R)-3-hydroxypyrrolidine-1-carbonyl]thieno[3,2-b]pyridine

Product 1

HCID 23401171HCID 23401171, compound

Procedure

The title compound was prepared from 1-bromo-2-methoxy-ethane and (3R)-(3-hydroxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone by a procedure analogous to Example 67B. MS: 341.2/343.2 (MH+); HPLC Rf: 4.236 min.; HPLC purity: 77%.

Sources & evidence

ORD record
ord-ea6b0d90527e4325a92a1d324ed53c55
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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