4-Amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine → 4-Amino-3,5-dimethyl-3-ethylpiperidine

HRID 1063341Notes

Reaction equation

HRID 1063341 reaction equation
[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][C:3]1([CH3:18])[CH2:16][CH3:17]>CO.[H][H].[OH-].[OH-].[Pd+2]>[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][NH:5][CH2:4][C:3]1([CH3:18])[CH2:16][CH3:17]

Participants

5

Reactant 1

HCID 102145914-Amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine

Product 1

HCID 101250824-Amino-3,5-dimethyl-3-ethylpiperidine

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

A mixture of 20% Pd(OH)2 on carbon (0.4 g) and 4-amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine (2.2 g, 8.9 mmol) in methanol (15 ml) was stirred in hydrogen atmosphere (1 atm.) at 60° C. for 10 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-amino-3,5-dimethyl-3-ethylpiperidine as a semi solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-62b4dae9d9e4437ba20fb97ab8c32c6f
Source dataset
uspto-grants-2005_11
Patent number
US06964966B2

Reaction notes

Loading…