Hydrochloric Acid → 4-(6-Bromo-hexyloxy)-piperidine hydrochloride

HRID 1063360Notes

Reaction equation

HRID 1063360 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[Br:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]Br.[ClH:23]>>[ClH:23].[Br:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 123681,6-DibromohexaneHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 222794204-(6-Bromo-hexyloxy)-piperidine hydrochloride

Procedure

In analogy to example 1.2a and 1.3, reaction of 4-Hydroxy-piperidine-1-carboxylic-acid tert-butyl ester and 1,6-dibromohexane followed by treatment with 4N HCl yielded 4-(6-Bromo-hexyloxy)-piperidine hydrochloride, MS: 264 (MH+, 1Br).

Sources & evidence

ORD record
ord-a9d1ea24796740e4bf9bb755c8222f0c
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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