Diethylamine → HCID 10271029, compound

HRID 1063362Notes

Reaction equation

HRID 1063362 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1.[CH2:26]([NH:28][CH2:29][CH3:30])[CH3:27]>>[CH2:26]([N:28]([CH2:29][CH3:30])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:1][CH:2]1[CH2:7][CH2:6][N:5]([C:23](=[O:24])[CH2:22][C:19]2[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=2)[CH2:4][CH2:3]1)[CH3:27]

Participants

5

Reactant 4

HCID 8021DiethylamineHCID 81001,5-DibromopentaneHCID 79341Piperidin-4-olHCID 37449884-Fluorophenylacetyl chloride

Product 1

HCID 10271029HCID 10271029, compound

Procedure

In analogy to example 1.2a, 1.3, 1.4 and 1.5, reaction of 4-Hydroxy-piperidine with 1,5-dibromopentane, (4-fluoro-phenyl)-acetyl chloride and diethylamine yielded 1-[4-(5-Diethylamino-pentyloxy)-piperidin-1-yl]-2-(4-fluoro-phenyl)-ethanone, MS: 379 (MH+).

Sources & evidence

ORD record
ord-da4b754a70c145f4954b9acbb6dd5005
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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