1,5-Dibromopentane → HCID 10157489, compound

HRID 1063363Notes

Reaction equation

HRID 1063363 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1.[CH3:26][O:27][CH2:28][CH2:29][NH:30][CH3:31]>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([N:5]2[CH2:6][CH2:7][CH:2]([O:1][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:30]([CH2:29][CH2:28][O:27][CH3:26])[CH3:31])[CH2:3][CH2:4]2)=[O:24])=[CH:18][CH:17]=1

Participants

5

Reactant 4

HCID 81001,5-DibromopentaneHCID 79341Piperidin-4-olHCID 300977(2-Methoxyethyl)(methyl)amineHCID 37449884-Fluorophenylacetyl chloride

Product 1

HCID 10157489HCID 10157489, compound

Procedure

In analogy to example 1.2a, 1.3, 1.4 and 1.5, reaction of 4-Hydroxy-piperidine with 1,5-dibromopentane, (4-fluoro-phenyl)-acetyl chloride and N-(2-methoxyethyl)methylamine yielded 2-(4-Fluoro-phenyl)-1-(4-{5-[(2-methoxy-ethyl)-methyl-amino]-pentyloxy}-piperidin-1-yl)-ethanone, MS: 395 (MH+).

Sources & evidence

ORD record
ord-3135edda1cc44ef18f9a748cd175a519
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

Loading…