1,5-Dibromopentane → HCID 10134150, compound

HRID 1063364Notes

Reaction equation

HRID 1063364 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1.[CH3:26][NH:27][CH:28]1[CH2:30][CH2:29]1>>[CH:28]1([N:27]([CH3:26])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:1][CH:2]2[CH2:7][CH2:6][N:5]([C:23](=[O:24])[CH2:22][C:19]3[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=3)[CH2:4][CH2:3]2)[CH2:30][CH2:29]1

Participants

5

Reactant 4

HCID 81001,5-DibromopentaneHCID 79341Piperidin-4-olHCID 37449884-Fluorophenylacetyl chlorideHCID 11029756N-Methylcyclopropanamine

Product 1

HCID 10134150HCID 10134150, compound

Procedure

In analogy to example 1.2a, 1.3, 1.4 and 1.5, reaction of 4-Hydroxy-piperidine with 1,5-dibromopentane, (4-fluoro-phenyl)-acetyl chloride and N-methylcyclopropylamine yielded 1-{4-[5-(Cyclopropyl-methyl-amino)-pentyloxy]-piperidin-1-yl}-2-(4-fluoro-phenyl)-ethanone, MS: 377 (MH+).

Sources & evidence

ORD record
ord-a9c130b080d64a14b1101762a623411b
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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