反应详情

温度

0 °C

To a solution of N-(t-butoxycarbonylaminosulfonyloxy)-succinimide (272 mg), 2-methoxyethanol (84.4 mg) and triphenylphosphine (291 mg) in tetrahydrofuran (5 ml) was added diethyl azodicarboxylate (193 mg) under ice-water cooling and the mixture was stirred at 0° C. for 1 hour. After evaporation of solvent, the residue was purified by silica gel column chromatography eluting with a mixture of hexane and ethyl acetate (2:1, 1:1) to give N-(N-t-butoxycarbonyl-N-(2-methoxyethyl)aminosulfonyloxy)succinimide as colorless oil (205 mg).

1. customAfter evaporation of solvent
2. customthe residue was purified by silica gel column chromatography
3. washeluting with a mixture of hexane and ethyl acetate (2:1, 1:1)