Potassium Hydroxide → HCID 23401660, compound

HRID 1063965Notes

Reaction equation

HRID 1063965 reaction equation
[C:1](C1N(CC[C@H](NS(C2C=CC=CC=2)(=O)=O)C)CCS1)([OH:3])=[O:2].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([S:30]([N:33]([C:47]2[CH:52]=[C:51]([Cl:53])[CH:50]=[CH:49][C:48]=2[Cl:54])[C@H:34]([CH3:46])[CH2:35][CH2:36][N:37]2[CH2:41][CH:40](CC(O)=O)[S:39][CH2:38]2)(=[O:32])=[O:31])=[CH:26][CH:25]=1.[OH-].[K+].[K+].[Br-]>>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([S:30]([N:33]([C:47]2[CH:52]=[C:51]([Cl:53])[CH:50]=[CH:49][C:48]=2[Cl:54])[C@H:34]([CH3:46])[CH2:35][CH2:36][N:37]2[CH2:41][CH:40]([C:1]([OH:3])=[O:2])[S:39][CH2:38]2)(=[O:31])=[O:32])=[CH:28][CH:29]=1

Participants

5

Reactant 4

HCID 14797Potassium HydroxideHCID 253877Potassium BromideHCID 23401661HCID 23401661, compoundHCID 86759907HCID 86759907, compound

Product 1

HCID 23401660HCID 23401660, compoundYield 70%

Procedure

4-chloro-N-(2,5-dichlorophenyl)-N-(3-(5-carboxy-3-thiazolidinyl)-1(R)-methylpropyl)benzenesulfonamide was prepared analogous to 4-chloro-N-2,5-dichlorophenyl)-N-(3-(2-carboxy-3-thiazolidinyl)-1(R)-methylpropyl)benzenesulfonamide by reacting 4-chloro-N-(2,5-dichlorophenyl)-N-(3-(5-carboxymethyl-3-thiazolidinyl)-1(R)-methylpropyl)benzenesulfonamide with 50% aqueous KOH. Yield=70%; White foam: IR (KBr) 1467, 1350, 1167, 1094, 753, 622 cm−1; MS (ESI+), 525 (M+H)+.

Sources & evidence

ORD record
ord-fbbd1274431f499a880d5d2b08fde359
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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