Potassium Hydroxide → HCID 23401681, compound

HRID 1063966Notes

Reaction equation

HRID 1063966 reaction equation
ClC1C=CC(S(N(C2C=C(Cl)C=CC=2Cl)[C@H](C)CCN2CCSC2[C:20]([OH:22])=[O:21])(=O)=O)=CC=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([N:42]([C:57]2[CH:62]=[C:61]([Cl:63])[CH:60]=[CH:59][C:58]=2[Cl:64])[C@H:43]([CH3:56])[CH2:44][CH2:45][CH2:46][N:47]2[CH2:51][CH:50](CC(O)=O)[S:49][CH2:48]2)(=[O:41])=[O:40])=[CH:35][CH:34]=1.[OH-].[K+].[K+].[Br-]>>[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([N:42]([C:57]2[CH:62]=[C:61]([Cl:63])[CH:60]=[CH:59][C:58]=2[Cl:64])[C@H:43]([CH3:56])[CH2:44][CH2:45][CH2:46][N:47]2[CH2:51][CH:50]([C:20]([OH:22])=[O:21])[S:49][CH2:48]2)(=[O:41])=[O:40])=[CH:35][CH:34]=1

Participants

5

Reactant 4

HCID 14797Potassium HydroxideHCID 253877Potassium BromideHCID 23401648HCID 23401648, compoundHCID 23401682HCID 23401682, compound

Product 1

HCID 23401681HCID 23401681, compoundYield 45%

Procedure

4-chloro-N-(2,5-dichlorophenyl)-N-(4-(5-carboxy-3-thiazolidinyl)-1(R)-methylbutyl)benzenesulfonamide was prepared analogous to 4-chloro-N-(2,5-dichlorophenyl)-N-(3-(2-carboxy-3-thiazolidinyl)-1(R)-methylpropyl)benzenesulfonamide by reacting 4-chloro-N-(2,5-dichlorophenyl)-N-(4-(5-carboxymethyl-3-thiazolidinyl)-1(R)-methylbutyl)benzenesulfonamide with 50% aqueous KOH. Yield=45%; White powder: IR (KBr) 1467, 1350, 1167, 1094, 754, 622 cm−1; MS (ESI+), 537 (M+H)+.

Sources & evidence

ORD record
ord-d003eeb4a4704597beb68dd4f7ec2e19
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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