Hydrochloric Acid → HCID 9928554, compound

HRID 1064076Notes

Reaction equation

HRID 1064076 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:17]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[C:16](=[O:32])[NH:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOCC.O1CCOCC1>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([C:17]2[C:16](=[O:32])[NH:15][N:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:18]=2[C:19]2[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=2)=[CH:26][CH:27]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69357048HCID 69357048, compound

Product 1

HCID 9928554HCID 9928554, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[4-(4-Chloro-phenyl)-3-oxo-5-pyridin-4-yl-2,3-dihydro-pyrazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 200 mg in flask was added HCl in ether and dioxane. After 2.25 hours, the solvent was evaporated under reduced pressure to afford the title compound as yellow oil. MS (ES+): 355 (M+H)+; (ES−): 353 (M−H).

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f3227960537d4a8588a4dfe254704bf8
Source dataset
uspto-grants-2005_11
Patent number
US06967254B2

Reaction notes

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