Pyridine → HCID 69355802, compound

HRID 1064080Notes

Reaction equation

HRID 1064080 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1.[C:21]([O:24]C(=O)C)(=[O:23])C.N1C=CC=CC=1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:19][C:16]2[CH:15]=[CH:14][N:13]=[CH:18][CH:17]=2)[C:10](=[O:12])[C:21]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

7

Reactant 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 133894-PyridinecarboxaldehydeHCID 798743,4-Dichlorophenylacetic acid

Product 1

HCID 69355802HCID 69355802, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

To mixture of (3,4-diChloro-phenyl)-acetic acid 10.3 g and pyridine-4-carbaldehyde 5.25 mL was added acetic anhydride 6 mL and pyridine 6 mL. The reaction mixture was heated to 120° C. for 2 hours and cooled down to room temperature. Water and ethyl acetate were added. The solid formed was filtered, washed with water and ethyl acetate and dried to afford the title compound 10.2 g as a light yellow solid. MS (ES+): 292 (M+H)+.

Workup

  1. temperaturecooled down to room temperature
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water and ethyl acetate
  5. customdried

Sources & evidence

ORD record
ord-f6a6dd6deb874fbe92a88efe556fddc6
Source dataset
uspto-grants-2005_11
Patent number
US06967254B2

Reaction notes

Loading…