Hydrochloric Acid → HCID 136411685, compound

HRID 1064163Notes

Reaction equation

HRID 1064163 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[C:14](=[O:36])[NH:15][C:16]1[CH:17]=[C:18]2[C:34](=[O:35])[NH:33][N:32]=[CH:31][C:20]3=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][C:23]([CH:24]=1)=[C:19]23)=O)(C)(C)C.Cl.O1CCOCC1>>[O:35]=[C:34]1[C:18]2[C:19]3[C:20](=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][C:23]=3[CH:24]=[C:16]([NH:15][C:14]([C@H:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[O:36])[CH:17]=2)[CH:31]=[N:32][NH:33]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 136343677HCID 136343677, compound

Product 1

HCID 136411685HCID 136411685, compound

Procedure

Preparation of the title compound from Intermediate 136(a) (0.16 g, 0.33 mmol) and 4M HCl in dioxane (1.6 mL, 6.6 mmol) was carried out analogously to Example 91. Isolation, also in an analogous manner, included a further trituration with CH2Cl2/diethyl ether and afforded the title compound (0.137 g) as an orange/yellow powder in 96% yield.

Sources & evidence

ORD record
ord-5ae32e7c616041cd843d9b78f15f18a8
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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