Hydrochloric Acid → HCID 135794602, compound

HRID 1064189Notes

Reaction equation

HRID 1064189 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[C:9](=[O:27])[NH:10][C:11]1[CH:12]=[C:13]2[C:25](=[O:26])[NH:24][N:23]=[CH:22][C:15]3=[C:16]([CH2:20][CH3:21])[NH:17][C:18]([CH:19]=1)=[C:14]23)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[C:9]([NH:10][C:11]1[CH:12]=[C:13]2[C:25](=[O:26])[NH:24][N:23]=[CH:22][C:15]3=[C:16]([CH2:20][CH3:21])[NH:17][C:18]([CH:19]=1)=[C:14]23)=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181641HCID 136181641, compound

Product 1

HCID 135794602HCID 135794602, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of the title compound from Intermediate 189(a) (136 mg, 0.291 mmol) and 4.0 M HCl in dioxane (1.5 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner, afforded the title compound (75 mg, 0.186 mmol) as a yellow powder in 64% yield.

Sources & evidence

ORD record
ord-aae0af601b864c11accd9cfb3e33aeb1
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

Loading…