Hydrochloric Acid → HCID 131725227, compound

HRID 1064564Notes

Reaction equation

HRID 1064564 reaction equation
[Cl:1]C1C=CC=CC=1N[C:9](=[O:29])[CH2:10][N:11]1[CH2:16][C@H:15]([CH3:17])[N:14]([C:18]2[N:26]=[CH:25][N:24]=[C:23]3[C:19]=2[N:20]=[CH:21][N:22]3[CH3:27])[C@H:13]([CH3:28])[CH2:12]1.Cl.C([O:33]CC)C>ClCCl>[ClH:1].[CH3:17][C@H:15]1[N:14]([C:18]2[N:26]=[CH:25][N:24]=[C:23]3[C:19]=2[N:20]=[CH:21][N:22]3[CH3:27])[C@@H:13]([CH3:28])[CH2:12][N:11]([CH2:10][C:9]([OH:29])=[O:33])[CH2:16]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 10158684HCID 10158684, compound

Product 1

HCID 131725227HCID 131725227, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from step (iii) (0.12 g) in dichloromethane was treated with 1M hydrogen chloride in diethyl ether (12 ml). The mixture was stirred at room temperature for 18 hours. The solvent was evaporated under reduced pressure to give the subtitle product as a pale yellow solid. Yield 0.15 g.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3f918e1f728e4fd28f73917c51967cb3
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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