Hydrochloric Acid → HCID 131725228, compound

HRID 1064566Notes

Reaction equation

HRID 1064566 reaction equation
[CH3:1][C@H:2]1[N:7]([C:8]2[C:9]3[CH:16]=[CH:15][S:14][C:10]=3[N:11]=[CH:12][N:13]=2)[C@@H:6]([CH3:17])[CH2:5][N:4]([CH2:18][C:19](NC2C=CC=C3C=2C=CN=C3)=[O:20])[CH2:3]1.[ClH:32].[O:33]1CCOCC1>>[ClH:32].[CH3:17][C@H:6]1[N:7]([C:8]2[C:9]3[CH:16]=[CH:15][S:14][C:10]=3[N:11]=[CH:12][N:13]=2)[C@@H:2]([CH3:1])[CH2:3][N:4]([CH2:18][C:19]([OH:20])=[O:33])[CH2:5]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-Dioxane2×HCID 10274446HCID 10274446, compound

Product 1

HCID 131725228HCID 131725228, compound

Procedure

The product from step (i) (1.0 g) in 1,4-dioxane was treated with 4M hydrogen chloride in 1,4-dioxane (40 ml). The mixture was stirred at room temperature for 18 hours. The solvent was evaporated under reduced pressure to give the subtitle compound as a white 15 solid. Yield 1.9 g.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-176c7d027c1e4fbeafdcf73ba871865d
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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