Hydrochloric Acid → 5-(Carbamoyl)-2,4,6-triiodoisophthalic acid

HRID 1065061노트

반응식

HRID 1065061 반응식
[C:1]([C:3]1[C:4]([I:17])=[C:5]([C:14]([OH:16])=[O:15])[C:6]([I:13])=[C:7]([C:11]=1[I:12])[C:8]([OH:10])=[O:9])#[N:2].[OH-:18].[Na+].Cl>O>[C:1]([C:3]1[C:11]([I:12])=[C:7]([C:8]([OH:10])=[O:9])[C:6]([I:13])=[C:5]([C:4]=1[I:17])[C:14]([OH:16])=[O:15])(=[O:18])[NH2:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 30184445-Cyano-2,4,6-triiodoisophthalic acid

생성물 1

HCID 30188205-(Carbamoyl)-2,4,6-triiodoisophthalic acid수율 95%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

100 g of 5-cyano-2,4,6-triiodoisophthalic acid is suspended in 400 ml of water and dissolved by adding 20 g of sodium hydroxide. The solution is maintained at +60° C. for 3 hours, then poured under stirring into 60 ml of concentrated hydrochloric acid. After several hours of agitation in an ice bath the precipitated product is vacuum-filtered, washed with a small amount of ice-cold water, and dried at 50° C., thus obtaining 98 g of 5-carbamoyl-2,4,6-triiodoisophthalic acid as a white powder having a decomposition point of above 280° C.

후처리

  1. dissolutiondissolved
  2. temperatureThe solution is maintained at +60° C. for 3 hours
  3. additionpoured
  4. filtrationAfter several hours of agitation in an ice bath the precipitated product is vacuum-filtered
  5. washwashed with a small amount of ice-cold water
  6. customdried at 50° C.

출처 및 근거

ORD 기록
ord-cb60667173754ba28ff1ee63c353fcf4
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04328202

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