反应详情

To the solution of 1.6 g of 4-aminopyridine in 7 ml of dimethylformamide 2 g of 2-chloroethylisocyanate are added while stirring and keeping the temperature below 40°. After 2 hours 28 ml of water are added and stirring is continued for 2 hours at room temperature. The precipitate formed is filtered off, washed with water, dried and recrystallized from aqueous ethanol, to yield the 1-(4-pyridyl)-3-(2-chloroethyl)-urea melting at 120°-122°.

1. customthe temperature below 40°
2. stirringstirring
3. customThe precipitate formed
4. filtrationis filtered off
5. washwashed with water
6. customdried
7. customrecrystallized from aqueous ethanol