Toluene → HCID 20540237, compound

HRID 1065274Notes

Reaction equation

HRID 1065274 reaction equation
O=[C:2]1[CH2:7][CH2:6][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)([C:8]#[N:9])[CH2:4][CH2:3]1.[C:16]1([N:22]2[C:26]3([CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[C:25](=[O:32])[NH:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CC1C=CC(S(O)(=O)=O)=CC=1.CC1C=CC=CC=1>O>[O:32]=[C:25]1[C:26]2([CH2:27][CH2:28][N:29]([C:2]3[CH2:7][CH2:6][C:5]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)([C:8]#[N:9])[CH2:4][CH:3]=3)[CH2:30][CH2:31]2)[N:22]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:23][NH:24]1

Participants

6

Reactant 4

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 912824-Oxo-1-phenylcyclohexanenitrile

Product 1

HCID 20540237HCID 20540237, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5 parts of 4-oxo-1-phenyl-1-cyclohexanecarbonitrile, 5.8 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 0.1 parts of 4-methylbenzenesulfonic acid and 225 parts of methylbenzene is stirred and refluxed overnight with water-separator. The reaction mixture is cooled and evaporated, yielding 10.35 parts of 4-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)-1-phenyl-3-cyclohexene-1-carbonitrile as a residue.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-7ab6cbbe6b1445fe8303faaecf61c59c
Source dataset
uspto-grants-1982_05
Patent number
US04329353

Reaction notes

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