Dimethylformamide → N-acetyl-2-(triphenylmethylthio)acetamide

HRID 1065299Notes

Reaction equation

HRID 1065299 reaction equation
[C:1]1([C:7]([SH:20])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN(C)C=O.C(N(CC)CC)C.[C:33]([NH:36][C:37](=[O:40])[CH2:38]Cl)(=[O:35])[CH3:34]>O>[C:33]([NH:36][C:37](=[O:40])[CH2:38][S:20][C:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:35])[CH3:34]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 77281Benzenemethanethiol, alpha,alpha-diphenyl-HCID 2366697N-acetyl-2-chloroacetamide

Product 1

HCID 12837901N-acetyl-2-(triphenylmethylthio)acetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 100.4 g. (0.40 mole) of triphenylmethylmercaptan in 500 ml. of dry dimethylformamide was added 40.4 g. (0.40 mole) of dry triethylamine. The reaction mixture was cooled in ice and stirred as portions of 54.2 g. (0.40 mole) of the product of Step A above were added over 10 minutes. The reaction mixture was stirred an additional hour with ice cooling and then overnight at room temperature. Water was then added carefully to the reaction mixture until just before the cloud point, when the mixture was seeded and crystallization began. Yield of product was 98.5 g. with an m.p. of 147°-149° C.

Workup

  1. additionTo a suspension of 100.4 g
  2. temperatureThe reaction mixture was cooled in ice
  3. stirringThe reaction mixture was stirred an additional hour with ice cooling
  4. customovernight
  5. customat room temperature
  6. customcrystallization

Sources & evidence

ORD record
ord-a5c19b6e06d8483db027eb955b573a77
Source dataset
uspto-grants-1982_05
Patent number
US04329363

Reaction notes

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