Thiophenol → HCID 54278658, compound

HRID 1065422Notes

Reaction equation

HRID 1065422 reaction equation
[C:1]1([CH2:9]Cl)[CH:6]=[CH:5][C:4]([CH2:7]Cl)=[CH:3][CH:2]=1.[C:11]1([SH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].C1(C(S)C2C=CC(CCl)=CC=2)C=CC=CC=1.[OH:40][C:41]1[CH:42]=[C:43]2[C:48](=[CH:49][CH:50]=1)[NH:47][C:46](=[O:51])[CH2:45][CH2:44]2>CS(C)=O>[C:11]1([S:17][CH2:9][C:1]2[CH:6]=[CH:5][C:4]([CH2:7][O:40][C:41]3[CH:42]=[C:43]4[C:48](=[CH:49][CH:50]=3)[NH:47][C:46](=[O:51])[CH2:45][CH2:44]4)=[CH:3][CH:2]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

7

Reactant 5

HCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 12171alpha,alpha'-Dichloro-p-xyleneHCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinoneHCID 20539969HCID 20539969, compound

Product 1

HCID 54278658HCID 54278658, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

p-Xylylene dichloride was reacted with thiophenol in a mol ratio of 1:1 in the presence of excess potassium carbonate in dimethylsulfoxide. The obtained 4-(phenyl-mercapto-methyl)-benzyl chloride (identification: thin-layer chromatogram) was further reacted with 6-hydroxy-3, 4-dihydro-carbostyril analogous to Example 140 without isolation.

Sources & evidence

ORD record
ord-3da45e9a5a6e4bbeb1c506f795f13a14
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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