Isopropyl isocyanate → HCID 12850188, compound

HRID 1065597Notes

Reaction equation

HRID 1065597 reaction equation
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:24]=[CH:23][C:16]([O:17][CH:18]([CH3:22])[C:19]([NH2:21])=[O:20])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH:25]([N:28]=[C:29]=[O:30])([CH3:27])[CH3:26]>C1(C)C=CC=CC=1>[CH:25]([NH:28][C:29]([NH:21][C:19](=[O:20])[CH:18]([O:17][C:16]1[CH:23]=[CH:24][C:13]([O:12][C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=2)=[CH:14][CH:15]=1)[CH3:22])=[O:30])([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 12850186HCID 12850186, compound

Product 1

HCID 12850188HCID 12850188, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-(4-((3-Chloro-5-(trifluoromethyl)-2-pyridyl)-oxy)phenoxy)propanamide (3.6 g, 0.01 mole) was dissolved in 80 ml. dry toluene. Isopropyl isocyanate (2.55 g, 0.03 mole) was then added and the mixture refluxed for about 16 hours. The toluene was removed by distillation and cold hexane was added. The product precipitated as white crystals, m.p. 135°-137° C.; Yield 3.6 g; 80.7%.

Workup

  1. temperaturethe mixture refluxed for about 16 hours
  2. customThe toluene was removed by distillation and cold hexane
  3. additionwas added
  4. customThe product precipitated as white crystals, m.p. 135°-137° C.

Sources & evidence

ORD record
ord-2eee87d4b02e47f295fdccda39a7835a
Source dataset
uspto-grants-1982_05
Patent number
US04330321

Reaction notes

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