2-Chloroquinoline → N-Methyl-3-phenyl-3-(2-quinolyloxy)propylamine

HRID 1065636Notes

Reaction equation

HRID 1065636 reaction equation
[OH:1][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][NH:5][CH3:6].[H-].[Na+].Cl[C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1>CS(C)=O>[CH3:6][NH:5][CH2:4][CH2:3][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[O:1][C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1

Participants

5

Reactant 3

HCID 119282-ChloroquinolineHCID 24758Sodium hydrideHCID 27339893-Methylamino-1-phenylpropanol

Product 1

HCID 20539674N-Methyl-3-phenyl-3-(2-quinolyloxy)propylamine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Following the method of Example 4, reaction of 3-hydroxy-N-methyl-3-phenylpropylamine, sodium hydride and 2-chloroquinoline in DMSO gives the title compound.

Sources & evidence

ORD record
ord-67e5b6efb350441ca2329c3af8282cad
Source dataset
uspto-grants-1982_05
Patent number
US04330546

Reaction notes

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