Water → HCID 131712720, compound

HRID 1065639Notes

Reaction equation

HRID 1065639 reaction equation
[C:1]1([C:7]2[O:11][C:10](=[O:12])[NH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13]([O:15][C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N:25]=[C:26]=[O:27])=[O:17])[CH3:14].O>CN(C=O)C>[CH2:13]([O:15][C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]([N:9]1[CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:11][C:10]1=[O:12])=[O:27])=[O:17])[CH3:14]

Participants

5

Reactant 3

HCID 962WaterHCID 123069965-Phenyl-1,3-oxazol-2-olHCID 13991420HCID 13991420, compound

Product 1

HCID 131712720HCID 131712720, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

16.1 g (0.1 mol) of 5-phenyl-4-oxazolin-2-one are dissolved in 100 ml of absolute DMF and 25.6 g (0.12 mol) of ethoxycarbonylheptyl isocyanate are added. The mixture is stirred for 24 hours at 50°-60° C., water is added and the oily/crystalline precipitate which is formed is separated, washed with water and dried in vacuo at room temperature. The crude product is recrystallised from ethanol.

Workup

  1. customthe oily/crystalline precipitate which is formed
  2. customis separated
  3. washwashed with water
  4. customdried in vacuo at room temperature
  5. customThe crude product is recrystallised from ethanol

Sources & evidence

ORD record
ord-02add52faab644d886d1a7657315e72b
Source dataset
uspto-grants-1982_05
Patent number
US04330550

Reaction notes

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