Hydrazine hydrate (1:1) → HCID 20538683, compound

HRID 1065797Notes

Reaction equation

HRID 1065797 reaction equation
[CH3:1][C:2]([CH3:12])([CH3:11])[C:3](=O)[CH:4]=[C:5](SC)[S:6]C.O.[NH2:14][NH2:15]>C(O)C>[C:2]([C:3]1[N:14]=[N:15][C:5](=[S:6])[CH:4]=1)([CH3:12])([CH3:11])[CH3:1]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 28197434,4-Dimethyl-1,1-bis(methylsulfanyl)pent-1-en-3-one

Product 1

HCID 20538683HCID 20538683, compoundYield 56.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 4,4-dimethyl-1,1-bis(methylthio)-1-penten-3-one (18.4 g) in ethanol, was added dropwise with stirring hydrazine hydrate (5.3 g), keeping the temperature below 25°. The reaction mixture was stirred briefly at room temperature, then refluxed for 2 hours. Evaporation of the solvent, and trituration with ether, afforded 3-t-butylpyrazole-5-thione (7.8 g, 20% yield), of melting point 147°-8°.

Workup

  1. customthe temperature below 25°
  2. temperaturerefluxed for 2 hours
  3. customEvaporation of the solvent, and trituration with ether

Sources & evidence

ORD record
ord-9de13d756b8b46f387d3311635e64774
Source dataset
uspto-grants-1982_05
Patent number
US04331678

Reaction notes

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