Potassium Carbonate → HCID 21197764, compound

HRID 1066090Notes

Reaction equation

HRID 1066090 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[S:12]([NH2:15])(=[O:14])=[O:13].C(=O)([O-])[O-].[K+].[K+].[CH:22]([N:25]=[C:26]=[S:27])([CH3:24])[CH3:23]>CC(C)=O>[NH2:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:9])=[O:10])[CH:5]=[CH:4][C:3]=1[S:12]([NH:15][C:26]([NH:25][CH:22]([CH3:24])[CH3:23])=[S:27])(=[O:14])=[O:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 75263Isopropyl IsothiocyanateHCID 21197860HCID 21197860, compound

Product 1

HCID 21197764HCID 21197764, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 2-amino-4-methanesulfonylbenzenesulfonamide (2.5 g), potassium carbonate (1.66 g) and isopropyl isothiocyanate (1.22 g) in 20 ml of dry acetone was heated at 50° C. for 18 h. Then the reaction mixture was evaporated in vacuo and the residue was dissolved in 25 ml of water. Then the solution was adjusted to pH 2 by dropwise addition of 4 M HCl at 0° C. with stirring. After stirring for 2 h the product was filtered off and dried, yielding the title compound as white crystals; m.p. 151-153° C.

Workup

  1. customThen the reaction mixture was evaporated in vacuo
  2. dissolutionthe residue was dissolved in 25 ml of water
  3. additionThen the solution was adjusted to pH 2 by dropwise addition of 4 M HCl at 0° C.
  4. stirringAfter stirring for 2 h the product
  5. filtrationwas filtered off
  6. customdried

Sources & evidence

ORD record
ord-5db3d4d986694a549928e4ee8ca59987
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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