反应详情

4,5-Dihydro-8-methylthio-2-phenylbenzo[2,1-c:3,4-b′]dithiophene-6-carboxylic acid (0.50 g) was dissolved in tetrahydrofuran (10 ml); oxazolyl chloride (0.15 ml) and then N,N-dimethylformamide (one drop) were added. After the mixture was stirred at room temperature for 2 hours, it was concentrated under reduced pressure. The residue was dissolved in tetrahydrofuran (30 ml); concentrated aqueous ammonia (5 ml) was added. After the reaction mixture was stirred at room temperature for one hour, it was poured over water and extracted with chloroform-methanol the organic layer was washed with water and dried (MgSO4), after which the solvent was distilled off to yield 4,5-dihydro-8-methylthio-2-phenylbenzo[2,1-c:3,4-b′]dithiophene-6-carboxamide (0.28 g, 56%), which was recrystallized from ethanol. Melting point 192-193° C.

1. concentrationit was concentrated under reduced pressure
2. dissolutionThe residue was dissolved in tetrahydrofuran (30 ml)
3. additionconcentrated aqueous ammonia (5 ml) was added
4. stirringAfter the reaction mixture was stirred at room temperature for one hour
5. additionit was poured over water
6. extractionextracted with chloroform-methanol the organic layer
7. washwas washed with water
8. dry with materialdried (MgSO4)
9. distillationafter which the solvent was distilled off