反应详情

To a solution of 5-methoxy-2-methylaniline (7.62 g) and triethylamine (15.5 ml) in dichloromethane (150 ml) at 0-5° C. was added chloroacetyl chloride (5.0 ml) dropwise and the ice bath removed. The resulting reaction mixture was stirred for 45 min before being poured into dil HCl and extracted with dichloromethane. Organic extracts were combined, washed with water, dried (Na2SO4) and concentrated to give a brown solid that was triturated with diethyl ether to leave the sub-title compound as a beige solid (5.7 g).

1. customthe ice bath removed
2. customThe resulting reaction mixture
3. extractionextracted with dichloromethane
4. washwashed with water
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customto give a brown solid that
8. customwas triturated with diethyl ether