反应详情

To a solution of 2-bromo-4-chlorotoluene (20.0 g; 97.3 mmol) in 300 mL of THF at −78° C. was added dropwise a 2.5 M solution of n-BuLi (102.2 mmol). After 30 min of stirring at that temperature, 1-formylpiperidine (11.4 mL) in 10 mL of THF was added and the solution left for 1 h. It was brought to 0° C. , quenched with NH4OAc (25%) and diluted with EtOAc. The organic phase was dried over Na2SO4, filtered and the solvent removed to yield 13.3 g of the title compound.

1. additionwas added
2. customwas brought to 0° C.
3. customquenched with NH4OAc (25%)
4. additiondiluted with EtOAc
5. dry with materialThe organic phase was dried over Na2SO4
6. filtrationfiltered
7. customthe solvent removed