反应详情

Utilizing the procedures of Examples 50 and 51, 2′,3′-O-dibutylstannylene uridine (19.1 g) was treated with bromopentane (7 ml, 1.3 eq.) and sodium iodide (4.5 g) in DMF (90 ml). Purification on a silica gel column utilizing NeOH/CH2Cl2 5%→10% yielded the a mixture of 2′ and 3′ isomers; of the product as a dark oil (9.8 g).

1. customPurification on a silica gel column
2. customyielded
3. additionthe a mixture of 2′ and 3′ isomers