反应详情

To a stirred mixture of 2.7 g (10 mmol) of 2-(4-methoxy-benzenesulfonyl)propionic acid ethyl ester, 3.03 gm (10 mmol) 4-(2-piperidin-1-yl-ethoxy)benzyl chloride, 10 gm of K2CO3 and 500 mg of 18-crown-6 in 250 ml of acetone was refluxed for 16 hours. At the end, the reaction mixture was filtered and the acetone layer was concentrated to a residue. The residue was extracted with chloroform, washed well with water, dried over anhydrous MgSO4, filtered and concentrated to a residue. The residue obtained was purified by silica-gel column chromatography by eluting with 50% ethyl acetate-hexanes to afford 4.8 gm (92%) of the desired product as an oil. MS: 490(M+H)+.

1. temperaturewas refluxed for 16 hours
2. filtrationAt the end, the reaction mixture was filtered
3. concentrationthe acetone layer was concentrated to a residue
4. extractionThe residue was extracted with chloroform
5. washwashed well with water
6. dry with materialdried over anhydrous MgSO4
7. filtrationfiltered
8. concentrationconcentrated to a residue
9. customThe residue obtained
10. customwas purified by silica-gel column chromatography
11. washby eluting with 50% ethyl acetate-hexanes