Imidazole → HCID 15838445, compound

HRID 1066435Notes

Reaction equation

HRID 1066435 reaction equation
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N1C=CN=C1.[I:25]I.[CH3:27][C:28]1([CH3:52])[C:32](=[O:33])[N:31]([C:34]2[CH:41]=[CH:40][C:37]([C:38]#[N:39])=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)[C:30](=[O:46])[N:29]1[CH2:47][CH2:48][CH2:49][CH2:50]O>C(Cl)Cl>[CH3:27][C:28]1([CH3:52])[C:32](=[O:33])[N:31]([C:34]2[CH:41]=[CH:40][C:37]([C:38]#[N:39])=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)[C:30](=[O:46])[N:29]1[CH2:47][CH2:48][CH2:49][CH2:50][I:25]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 807IodineHCID 11776TriphenylphosphineHCID 1329814-(3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile

Product 1

HCID 15838445HCID 15838445, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

787 mg of triphenyl phosphine, 204 mg of imidazole, 762 mg of iodine and 5 ml of methylene chloride are introduced, the suspension is agitated for 45 minutes at ambient temperature, then over about 3 minutes, 1.1 g of 4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxybutyl)-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile obtained in Example 1 of EP 0,580,459 in 7 ml of methylene chloride is added. Rinsing is carried out with 1 ml of methylene chloride followed by agitation for 4 hours at ambient temperature.

Workup

  1. waitover about 3 minutes
  2. washRinsing
  3. waitfollowed by agitation for 4 hours at ambient temperature

Sources & evidence

ORD record
ord-6e48c9b7cb8c4d90a0bc6e68af2c237a
Source dataset
uspto-grants-2001_06
Patent number
US06242611B1

Reaction notes

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