Succinic anhydride → 213186-60-8

HRID 1066562Notes

Reaction equation

HRID 1066562 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:13]1(=[O:19])[O:18][C:16](=[O:17])[CH2:15][CH2:14]1>CN(C)C=O>[O:19]=[C:13]([N:10]1[CH2:11][CH2:12][N:7]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:8][CH2:9]1)[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 887471-(2-Pyrimidinyl)piperazine

Product 1

HCID 2815239213186-60-8Yield 70.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(2-pyrimidinyl)piperazine (3.28 g) and succinic anhydride (2.2 g) in dimethylformamide (15 ml) was stirred for 1 hour at room temperature. The reaction mixture was concentrated under reduced pressure and the concentrate was recrystallized from ethanol/ethyl ether to give the titled compound (3.73 g) as a colorless crystal.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe concentrate was recrystallized from ethanol/ethyl ether

Sources & evidence

ORD record
ord-f99fd9744ddf4a91b410ac7ee12e96e7
Source dataset
uspto-grants-2001_06
Patent number
US06242600B1

Reaction notes

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