HRID1066707

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O$

HCID9920342

Sorbitan, mono-(9Z)-9-octadecenoate

C24H44O6

HCID54670067

L-Ascorbic acid

C6H8O6

结构：O=C1O[C@H]([C@@H](O)CO)C(O)=C1O.OCC(O)CO

HCID131722625

未命名化合物

2 次

PRODUCTS

生成物

$结构：CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O.OCC(O)CO$

HCID131722624

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID753

Glycerol

C3H8O3

PROCEDURE

实验过程

L-Ascorbic acid (50 mg) was dissolved in a 1 mL glycerol solution by heating and stirring the mixture. After being cooled to room temperature, the ascorbic acid/glycerol solution was mixed with GCSF powder (45.3 mg) and Span 80 (250 mL). 3.75 mL thickened oil (3% AIMS) prepared as described above was added to the G-CSF/ascorbic acid/glycerol mixture and ground together to give a viscous oil suspension (G-CSF/20% glycerol+ascorbic acid/Span 80/3% AIMS/oil).

WORKUP

后处理

temperatureby heating

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac8f2f07d82e4924bd96664d332a8bca
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06245740B1
来源说明: uspto-grants-2001_06

反应 SMILES

[O:1]=[C:2]1O[C@H]([C@H](CO)O)[C:5]([OH:6])=[C:3]1[OH:4].[O:13]=[C:14]1[O:20][C@H:19]([C@H:21]([CH2:23][OH:24])[OH:22])[C:17]([OH:18])=[C:15]1[OH:16].OCC(CO)O.[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]/[CH:39]=[CH:40]\[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][C:48]([O:50][CH2:51][C@@H:52]([OH:60])[C@H:53]1[O:57][CH2:56][C@H:55]([OH:58])[C@H:54]1[OH:59])=[O:49]>OCC(CO)O>[OH:1][CH2:2][CH:3]([CH2:5][OH:6])[OH:4].[O:13]=[C:14]1[O:20][C@H:19]([C@H:21]([CH2:23][OH:24])[OH:22])[C:17]([OH:18])=[C:15]1[OH:16].[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]/[CH:39]=[CH:40]\[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][C:48]([O:50][CH2:51][C@@H:52]([OH:60])[C@H:53]1[O:57][CH2:56][C@H:55]([OH:58])[C@H:54]1[OH:59])=[O:49]