Dimethylformamide → 4-Methoxy-3-(trifluoromethyl)benzoyl chloride

HRID 1066775Notes

Reaction equation

HRID 1066775 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].C(Cl)(=O)C([Cl:19])=O.CN(C=O)C>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:19])=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27752954-Methoxy-3-(trifluoromethyl)benzoic acid

Product 1

HCID 27752984-Methoxy-3-(trifluoromethyl)benzoyl chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from 4-methoxy-3-trifluoromethylbenzoic acid with oxalyl chloride and DMF in chloroform at room temperature [D. Levin, Chem. Br., 1977, 20] followed by evaporation in vacuo.

Workup

  1. customfollowed by evaporation in vacuo

Sources & evidence

ORD record
ord-066b3daf240f4fedbfc5a28898dd9cd2
Source dataset
uspto-grants-2001_06
Patent number
US06245778B1

Reaction notes

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