1-Piperidinamine, N,N-dimethyl- → HCID 54146532, compound

HRID 1066800Notes

Reaction equation

HRID 1066800 reaction equation
CN([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)C.[Cl:10][C:11]1[CH:33]=[CH:32][C:14]([O:15][CH2:16][C:17]2[N:18]([CH3:31])[C:19]3[C:24]([C:25]=2[CH:26]=[CH:27][C:28](O)=[O:29])=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][CH:12]=1.Cl.[CH3:35][N:36](C)[CH2:37]CCN=C=NCC>C(Cl)Cl>[Cl:10][C:11]1[CH:33]=[CH:32][C:14]([O:15][CH2:16][C:17]2[N:18]([CH3:31])[C:19]3[C:24]([C:25]=2[CH:26]=[CH:27][C:28]([N:4]2[CH2:5][CH2:6][CH:7]([N:36]([CH3:37])[CH3:35])[CH2:8][CH2:9]2)=[O:29])=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 1426901-Piperidinamine, N,N-dimethyl-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 54353537HCID 54353537, compound

Product 1

HCID 54146532HCID 54146532, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Under a nitrogen atmosphere dimethylaminopiperidine was dissolved in 3.0 ml of methylene chloride. To this solution were added 3-(2-[(4-chlorophenoxy)methyl]-1-methyl-1H-indol-3-yl]prop-2-enoic acid (0.050 g, 0.1462 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.0356 g, 0.278 mmol). The resulting mixture was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-feba1f9b7c3f4d1cb2bb54f9d488f296
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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