Dimethylformamide → HCID 18551249, compound

HRID 1066924Notes

Reaction equation

HRID 1066924 reaction equation
C(O[C:4](=[O:24])[C:5]([OH:23])([C:19]([F:22])([F:21])[F:20])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[C:12]([O:17][CH3:18])[CH:11]=1)([CH3:9])[CH3:8])C.C([Sn](CCCC)(CCCC)[C:30]([O:32]CC)=[CH2:31])CCC.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.CN(C)C=[O:68]>>[C:30]([C:13]1[CH:14]=[CH:15][C:10]([C:7]([CH3:8])([CH3:9])[CH2:6][C:5]([OH:23])([C:19]([F:22])([F:20])[F:21])[C:4]([OH:68])=[O:24])=[CH:11][C:12]=1[O:17][CH3:18])(=[O:32])[CH3:31]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 80271Tri-o-tolylphosphineHCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 17935599HCID 17935599, compound

Product 1

HCID 18551249HCID 18551249, compound

Procedure

Analogously to the compound above of 4-(4-bromo-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, tributyl-1-ethoxyvinyltin, tri-o-tolylphosphine and bis-tri-o-tolylphosphine-palladium(II) chloride in dimethylformamide to 120° C., oil.

Workup

  1. customto 120° C.

Sources & evidence

ORD record
ord-bd0d7343181d4e50ac9311fd96a4723c
Source dataset
uspto-grants-2001_06
Patent number
US06245804B1

Reaction notes

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