Hydrochloric Acid → HCID 178502825, compound

HRID 1067163Notes

Reaction equation

HRID 1067163 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].Cl>O>[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 178418600HCID 178418600, compound3×HCID 178502822HCID 178502822, compound2×

Product 1

HCID 178502825HCID 178502825, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

About 582 mg (3.34 mole) of particulate arginine was dissolved in 50 ml of distilled water. Additionally, about 1.0 grams (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N-HCl until the pH reached 6.0. The ceftriaxone solution was then added to the arginine solution and stirred by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-arginine solution. To the ceftriaxone-arginine solution was added about 400 mg of carrageenan and the solution was stirred by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-arginine-carrageenan complex was formed which was freeze-dried while in the swollen state, yielding about 1.84 g of the freeze dried complex.

Sources & evidence

ORD record
ord-35d26ea3d04d43a59978e30abc855c17
Source dataset
uspto-grants-2001_06
Patent number
US06248360B1

Reaction notes

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