Hydrochloric Acid → HCID 178478796, compound

HRID 1067221Notes

Reaction equation

HRID 1067221 reaction equation
[NH:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([S:15](=[O:18])(=[O:17])[NH2:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[C:2]([NH2:4])=[NH:3].[ClH:19]>C(O)C>[ClH:19].[ClH:19].[NH:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([S:15](=[O:17])(=[O:18])[NH2:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178512626HCID 178512626, compound

Product 1

HCID 178478796HCID 178478796, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Guanidino-7-sulphamoylisoquinoline (12 mg, 0.045 mmol) was dissolved in a solution of ethanol saturated with HCl gas (1.0 mL) and the mixture was stirred at room temperature for 1 hour. The solvents were evaporated in vacuo and the residue was azeotroped with dichloromethane (CH2Cl2) to give 1-guanidino-7-sulphamoylisoquinoline dihydrochloride (13 mg, 0.043 mmol) as a white solid.

Workup

  1. customThe solvents were evaporated in vacuo
  2. customthe residue was azeotroped with dichloromethane (CH2Cl2)

Sources & evidence

ORD record
ord-c469418715794444b8aeac6ae95ad142
Source dataset
uspto-grants-2001_06
Patent number
US06248738B1

Reaction notes

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