Butyl bromide → HCID 91293352, compound

HRID 1067272Notes

Reaction equation

HRID 1067272 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[O:9][C:10](=[O:18])[N:11]([CH:13]3[CH2:17][CH2:16][NH:15][CH2:14]3)[N:12]=2)[C:5]([O:19][CH3:20])=[CH:4][C:3]=1[NH:21][C:22](=[O:31])[O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(N(CC)CC)C.Br[CH2:40][CH2:41][CH2:42][CH3:43]>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[O:9][C:10](=[O:18])[N:11]([CH:13]3[CH2:17][CH2:16][N:15]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:14]3)[N:12]=2)[C:5]([O:19][CH3:20])=[CH:4][C:3]=1[NH:21][C:22](=[O:31])[O:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 8471TriethylamineHCID 9868116HCID 9868116, compound

Product 1

HCID 91293352HCID 91293352, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Conditions

Temperature
60 °C

Procedure

1.5 g (3.37 mmol) of phenylmethyl [2-chloro-4-(5-oxo-4-(pyrrolidin-3-yl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)-5-methoxyphenyl]carbamate dissolved in 26 ml of acetonitrile, and 1.41 ml (10.1 mmol) of triethylamine are placed in a 100 ml three-necked round-bottomed flask. A solution of 0.6 g (4.38 mmol) of 1-bromobutane in 4 ml of acetonitrile is added and the mixture is heated at 60° C. for 15 h.

Sources & evidence

ORD record
ord-e84f6cc1cd9c4fd48323cd13b0de8075
Source dataset
uspto-grants-2001_06
Patent number
US06248757B1

Reaction notes

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