Water → HCID 21192916, compound

HRID 1067296Notes

Reaction equation

HRID 1067296 reaction equation
[Cl:1][C:2]1[C:3]([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=2)=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][NH:9][CH2:8][CH2:7]2.C(N(CC)CC)C.[CH3:34][S:35](Cl)(=[O:37])=[O:36].O>ClCCl>[Cl:1][C:2]1[C:3]([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([C:22]([F:23])([F:24])[F:25])[CH:15]=2)=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][N:9]([S:35]([CH3:34])(=[O:37])=[O:36])[CH2:8][CH2:7]2

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 21192910HCID 21192910, compound

Product 1

HCID 21192916HCID 21192916, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(8-Chloro-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxy-3-trifluoromethylbenzamide (0.193 g) in dichloromethane (10 ml) containing triethylamine (0.055 ml) was treated with methanesulfonyl chloride ((0.063 g) and the mixture stirred for 48 h. Water was added and the organic phase separated and solvent removed at reduced pressure. The residue was triturated with diethyl ether to give the title compound (0.19 g).

Workup

  1. customthe organic phase separated
  2. customsolvent removed at reduced pressure
  3. customThe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-6b0cff0022524f21adf2008e70b9e883
Source dataset
uspto-grants-2001_06
Patent number
US06248754B1

Reaction notes

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